Source : J Clin Neurol 2022;18(4):478-480

Objective : Explored whether low-dose natural GABA (75 mg) is as effective in improving sleep quality and sleep efficacy as is high-dose natural GABA (300 mg), and without adverse events

Methods : This study screened 64 patients between September 18, 2018 and July 21, 2020. Ten individuals were excluded because they withdrew their consent before randomization. The remaining 54 patients were randomly allocated to receive either natural GABA (n=26) or a placebo (n=28), among whom 50 (25 natural GABA and 25 placebo) completed the study. Two of the participants (one from the control group and the other from the natural-GABA group) dropped out because they did not complete follow-up PSG, and two others dropped out from the control group because they withdrew their consent. The demographics did not differ significantly between the two groups. The mean age of the participants was 46 years, and 24% of them were male.

Conclusion : This study suggests that low-dose natural GABA (75 mg) is effective against sleep-onset insomnia, as supported by a decrease in PSG sleep latency without side effects.